Japonya’daki Osaka \u00dcniversitesi’nden bilim insanlar\u0131, ya\u015flanmay\u0131 h\u00fccresel d\u00fczeyde tersine \u00e7evirebilecek kritik bir protein olan AP2A1’i ke\u015ffetti. Ara\u015ft\u0131rmalara g\u00f6re, bu proteinin bask\u0131lanmas\u0131 ya\u015flanma s\u00fcrecini geriye d\u00f6nd\u00fcrebilirken, art\u0131\u015f\u0131 ise ya\u015flanmay\u0131 h\u0131zland\u0131r\u0131yor.<\/p>\n\n\n\n
Cellular Signaling dergisinde yay\u0131nlanan bu \u00e7al\u0131\u015fma, ya\u015fl\u0131 ve gen\u00e7 h\u00fccre durumlar\u0131 aras\u0131ndaki ge\u00e7i\u015fi y\u00f6neten AP2A1 proteininin ya\u015flanma s\u00fcrecindeki kritik rol\u00fcn\u00fc ortaya koyuyor. V\u00fccut ya\u015f ald\u0131k\u00e7a, daha az aktif olan ya\u015fl\u0131 h\u00fccreler organlarda birikiyor. Bu h\u00fccreler, gen\u00e7 h\u00fccrelerden \u00e7ok daha b\u00fcy\u00fck olup, stres liflerinin yap\u0131sal de\u011fi\u015fiklikleri gibi farkl\u0131l\u0131klar g\u00f6steriyor.<\/p>\n\n\n\n
\u00c7al\u0131\u015fman\u0131n ba\u015f yazlar\u0131ndan Pirawan Chantachotikul, “Ya\u015flanm\u0131\u015f h\u00fccrelerin neden b\u00fcy\u00fck kald\u0131\u011f\u0131n\u0131 h\u00e2l\u00e2 tam olarak anlam\u0131\u015f de\u011filiz. Ancak, stres liflerinin ya\u015flanm\u0131\u015f h\u00fccrelerde gen\u00e7 h\u00fccrelere g\u00f6re \u00e7ok daha kal\u0131n oldu\u011funu g\u00f6rd\u00fck. Bu, ya\u015flanm\u0131\u015f h\u00fccrelerin yap\u0131sal olarak farkl\u0131l\u0131klar g\u00f6stermesine neden olabilir” dedi.<\/p>\n\n\n\n
Ara\u015ft\u0131rmac\u0131lar, AP2A1 proteininin ya\u015flanm\u0131\u015f fibroblast ve epitel h\u00fccrelerinde daha yo\u011fun bulundu\u011funu tespit etti. AP2A1’in bask\u0131lanmas\u0131n\u0131n ya\u015flanm\u0131\u015f h\u00fccreleri yeniden canland\u0131rd\u0131\u011f\u0131, buna kar\u015f\u0131n gen\u00e7 h\u00fccrelerde fazla \u00fcretilmesinin ise ya\u015flanmay\u0131 h\u0131zland\u0131rd\u0131\u011f\u0131 g\u00f6zlemlendi.<\/p>\n\n\n\n
Ya\u015fl\u0131l\u0131kla Ba\u011fl\u0131 Hastal\u0131klar\u0131n Tedavisinde Umut I\u015f\u0131\u011f\u0131<\/strong><\/p>\n\n\n\n Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca, AP2A1’in, h\u00fccrelerin kolajen matrise tutunmalar\u0131na yard\u0131mc\u0131 olan integrin \u03b21 proteiniyle yak\u0131ndan ili\u015fkili oldu\u011funu ke\u015ffetti. Bu etkile\u015fimin, ya\u015flanm\u0131\u015f h\u00fccrelerin b\u00fcy\u00fck boyutunu ve \u00e7evresiyle etkile\u015fim yetene\u011fini a\u00e7\u0131klad\u0131\u011f\u0131 belirtiliyor.<\/p>\n\n\n\n Bu bulgular, AP2A1\u2019in sadece h\u00fccresel ya\u015flanma i\u00e7in bir belirte\u00e7 olarak kullan\u0131lmas\u0131n\u0131 de\u011fil, ayn\u0131 zamanda ya\u015fl\u0131l\u0131kla ili\u015fkili hastal\u0131klar i\u00e7in potansiyel bir tedavi hedefi olarak ele al\u0131nmas\u0131 gerekti\u011fini g\u00f6steriyor.<\/p>\n\n\n\n Bu \u00e7al\u0131\u015fma, gelecek y\u0131llarda ya\u015flanmaya ba\u011fl\u0131 hastal\u0131klar\u0131n tedavisinde devrim niteli\u011finde ad\u0131mlar\u0131n at\u0131lmas\u0131n\u0131 sa\u011flayabilir.<\/p>\n","protected":false},"excerpt":{"rendered":" Japonya’daki Osaka \u00dcniversitesi’nden bilim insanlar\u0131, ya\u015flanmay\u0131 h\u00fccresel d\u00fczeyde tersine \u00e7evirebilecek kritik bir protein olan AP2A1’i ke\u015ffetti. Ara\u015ft\u0131rmalara g\u00f6re, bu proteinin bask\u0131lanmas\u0131 ya\u015flanma s\u00fcrecini geriye d\u00f6nd\u00fcrebilirken, art\u0131\u015f\u0131 ise ya\u015flanmay\u0131 h\u0131zland\u0131r\u0131yor. Cellular Signaling dergisinde yay\u0131nlanan bu \u00e7al\u0131\u015fma, ya\u015fl\u0131 ve gen\u00e7 h\u00fccre durumlar\u0131 aras\u0131ndaki ge\u00e7i\u015fi y\u00f6neten AP2A1 proteininin ya\u015flanma s\u00fcrecindeki kritik rol\u00fcn\u00fc ortaya koyuyor. V\u00fccut ya\u015f ald\u0131k\u00e7a, daha […]<\/p>\n","protected":false},"author":1,"featured_media":130,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[28,11,27],"tags":[51,43,53,52],"class_list":["post-129","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-haber","category-saglik-tip","tag-ap2a1","tag-bilimveteknolojihaberleri","tag-osaka-universitesi","tag-yaslanmayi-baskilama"],"_links":{"self":[{"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/posts\/129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/comments?post=129"}],"version-history":[{"count":1,"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/posts\/129\/revisions"}],"predecessor-version":[{"id":131,"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/posts\/129\/revisions\/131"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/media\/130"}],"wp:attachment":[{"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/media?parent=129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/categories?post=129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimaktuel.com\/index.php\/wp-json\/wp\/v2\/tags?post=129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}